Remove the limitations of standard ported caps and mitigate the risk of contamination for tube-to-container interfaces.

• Open Architecture Means No Limits: Enable the integration of exactly the type of TPE/silicone tubing required by your application. This solution is not limited by tubing diameters or the number of lines, therefore very small and very large tubing can be integrated. There is also the option to easily integrate vent filters and aseptic ports – a key differentiator in perfectly matching the container system with your filling/draining operations.
• Seamless Integration Allows for Non-Stop Product Flow: The tubing is seamlessly integrated in the silicone stopper, which acts as a combined cap seal and tubing feed-through. The stopper is developed specifically for each container system, irrespective of the container size, material (PET, PC, glass) or brand – enabling full scalability to your application. As no connection is required between the tubing and the container, a continuous flow path is guaranteed during filling and emptying without any dead zones or protrusions disturbing the product’s laminar flow.
• Tamper-Proof for Handling, Transportation and Dispensing: We are the sealing experts and have extensive experience in developing customizable closure and tubing sizes and combining these solutions with state-of-the-art tubing manifold technology. Securing the tubing requires no cable ties because the tube-to-container interface seamlessly feeds through the tubing to the inside of the container. This proprietary tube-to-container interface is available for glass bottles in the form of "flex caps."

Our proprietary overmolding technology offers secure, tailored tube-to-tube connections in a wide variety of combinations.

• Overmolded connections are available in X, Y and T configurations and fully customizable. Due to our ability to integrate TPE and silicone tubing of any brand, tubing diameter and length, customers have the freedom to choose from their trusted and validated materials pool – a major benefit in reducing overall system costs. Our tube-to-tube connections are perfect for challenging final-fill and lab-scale applications with our small inner diameter tubing of 1.6mm.
• Parker's gateway solutions have no edges or protrusions in the fluid path, which eliminates dead zones and guarantees a laminar flow of the product through the gateway. The TPE/silicone overmolded gateways provide a tubing connection that meets even the harshest cold chain transportation requirements. Their material performance is on par with that of the TPE/silicone tubing utilized.

Eliminate the need for additional tubing connections with anti-foam and mixing solutions. The draining line continuously runs through the container system, thus mitigating any risk of contamination due to imperfect fluid flow while retrieving the product.

• Anti-Foam Solutions: Our J-Tube anti-foaming feature makes it possible to gently guide the product toward the wall of the bottle where it can flow downward as intended without frothing. Proprietary overmolding technology connects the J-Tube to the adjacent tubing in the same way as a tube-to-tube connection – eliminating any protrusion into the fluid path and guaranteeing a tamper-proof connection. The J-Tube is fully scalable to fit all container types regardless of size, type, or brand. The angle of the J-Tube can be adapted to the customer’s requirements so that the end of the J-Tube faces the container wall at exactly the desired position.
• In-Container Mixing: We can integrate magnetic stirring bars into containers, providing a ready-to-use, fully validated and sterilized system. This eliminates tube handling issues in mixing-draining processes to be performed in single containers. Our proprietary overmolding process ensures that the draining line is guided to the correct position on the container wall. This allows for a magnetic stirrer bar to be placed at the bottom of the container without any concerns about its uninterrupted operation due to collisions with the draining line.

Our container technology is used in various biopharma applications such as bubble traps designed to avoid air entrapments in vaccine production, waste containers to securely recycle by-product, and buffer systems that maximize safety by avoiding direct contact between fluids in two different serially connected bioreactors.

• Tamper-Proof Seal: Tamper-evidence seal ensures full visibility of a container closure mechanism’s integrity. The seal, consisting of two overmolding TPE bands that are chemically bonded to the cap and bottle neck and interconnected, cannot be physically destroyed without cutting the interconnection. It is superior to shrink films in terms of thermal stability, robustness, and ease-of-use. Scalable for all types of containers.
• Protection Cap: Customized protection caps can either cover cut-off or crimped tubing ends or guide tubing outside of the container into a position where it can be securely attached to the neck of the container. Easily applied by means of a click mechanism and manufactured from medical-grade plastics, cap shapes can be modified to suit the customer's container systems such as single-, dual- and multi-tubing systems.
• Tube Fixation: Tubing that needs to be attached to the container, can be secured to the container’s neck with our tube fixation feature that sits on the container's neck and enables easy tubing clip-in. The clip-ins are designed to fit the respective tubing diameter and can be adjusted in terms of their numbers and positioning for high levels of handling safety and ease of operation.

If you need to freeze your product or keep it extremely cold during storage and transportation, rely on us for your container needs up to -85C.

• Integrity Seal: The torque with which the cap is screwed onto the container’s body is another factor that affects sealing performance. Due to the differences of cap and body shrinkage in the freezing process, torque degrades. The resulting degradation of the contact force acting on the sealing interfaces entails the risk of gap formation between the container cap and body, and compromises sealing performance.
  
  Our patented integrity seal wraps around the circumference of the bottom edge of the cap and the upper part of the bottle neck. It is applied by overmolding and the proprietary sealing material bonds the cap to the body of the container.
  
  The integrity seal ensures significantly lower torque degradation during the freezing process because the cap is held securely in place relative to the container body. The integrity seal prevents any opening of the container – guarantying a closed system.
• Cold Chain Transport Containers: Our cold chain technology can be applied to all plastic containers (PET and PC) with a size factor from 125 ml to 20 l. We offer a container-integrated dip tube for easy and convenient draining, which can be produced from the same material as the container. Due to the system’s identical material profile, there are no concerns regarding leachables and extractables.
  
  After filling the container, tubing can easily be positioned in a secure way using the tube fixations and subsequently protected with a cap.
  
  We offer 100% helium leakage testing for every container. Using state-of-the-art mass spectrometry-based test methodologies, the container system is tested with 100% helium overpressure for sealing tightness. Every container tested is labeled with a unique product code for full traceability of the test results.

• As an independent systems integrator, Parker can implement all common single-use pharma components (tubing, vent filters, aseptic connectors, etc.) from approved manufacturers into custom-made tubing manifolds. These tubing manifolds are fully scalable from lab to production scale, mitigate the risk of contamination through excellent fluid path management, and help reduce overall system costs as customers continue using their internally validated and established brands and products.

• Parker’s overmolding technology enables secure tailor-made tube-to-tube connections in a wide variety of combinations (X, Y and T configurations are fully customizable). With our ability to integrate silicone and TPE tubing irrespective of tubing diameter, tubing length or brand provides customers with the freedom to choose from their trusted and validated material pool and thus a major benefit in terms of overall system cost reductions.
• Overmolding technology eliminates the need for cable ties, which ensures tamper-proof connection of various types of tubing and thus generates a closed system environment for processing your valuable product.

• Minimizing stress on your product as it progresses through its manufacturing process was one of the milestone goals in the design and development process of our gateway solutions. As a result, there are no edges or protrusions present in the fluid path. This eliminates dead zones, mitigates the risk of contamination, and guarantees laminar flow of the product through the gateway.
• The TPE/silicone overmolded gateways provide a tubing connection that meets even the harshest cold chain transportation requirements. Their material performance is on par with that of the TPE/silicone tubing used.

• We offer highly precise overmolded manifold systems for final filling applications. To perfectly process fluid on a low volume level, we developed a micro overmolding process enabling us to manufacture manifolds with an inner tubing diameter down to 1.6 mm – perfect for peristaltic pumps.

• In addition to our standard tube connectors, which are available for various sizes of TPE and silicone tubing, we have developed special traceability solutions. Our molded-label technology enables us to integrate custom-designed labels into overmolded X, Y, T or stopper connections to guarantee maximum traceability even under challenging environmental conditions such as autoclaving and beta/gamma irradiation cycles or in contact with aggressive media.

• Building on the excellent design flexibility of our tube-to-container interfaces, our design and process experts provide you with multi-functional cap solutions. Our smart product solutions mitigate the risk of contamination. The technology spectrum is fully scalable while our open architecture allows for the integration of previously validated components such as tubing and thus significantly helps reduce overall system costs.
• Any desired TPE/silicone tubing can be integrated into the cap interface. By design, the flex caps are not limited in terms of the number of lines present in the cap interface or the tubing diameter. Peripherals such as needles, aseptic ports and vent filters can thus be easily integrated to allow for maximum operational flexibility.

• Fluid management inside the bottle or container is facilitated by our anti-foam feature (“J-Tube”) and overmolding capability that enables tubing inside the bottle to be guided to the wall of the bottle. This allows for the integration of a draining line in parallel to a magnetic stirrer bar in the bottle in mixing applications.
• Also, no additional tubing connections are necessary due to the design of in-container tube management – the draining line continuously runs through the container system, thus mitigating any risk of contamination due to imperfect fluid flow while retrieving the product.

• Being seamlessly integrated in the silicone stopper that acts as a combined cap seal and tubing feed-through, the product flowing through the tubing follows a perfect flow path. Due to the absence of any additional connections between the outside tubing and the in-bottle tubing, there are no protrusions disturbing the product’s laminar flow. The elimination of dead zones in the fluid path mitigates the risk of contamination. Full scalability is ensured as every flex cap is designed specifically for any given bottle or container size, irrespective of the material (PET, PC, glass).